Master thesis position offered

B-cell responses are essential for humoral immunity against pathogens because they lead to the generation of antibody-secreting cells that produce large amounts of antigen-specific antibodies. These cells also have the potential to become quiescent and long-lived, which is fundamental for immunological memory against pathogens. B-cell responses are also key mediators of diseases, such as allergies, antibody-mediated autoimmunity, and tumor malignancies.

Our Group at the Institute of Allergy Research (IAF)/Center for Allergy and Environment (ZAUM) at Helmholtz and the Technical University of Munich focuses on studying the processes of B lymphocyte activation and differentiation into effector B cells, such as antibody-secreting cells and memory B cells. We are seeking a highly motivated Master’s student to join our research team for a thesis project.

The lab has previously established an in vivo model system for pooled single-guide RNA (sgRNA) CRISPR/Cas9 screening, which led to the identification of several novel regulators of B cell-mediated responses. Building on this expertise, the student’s project will focus on developing new in vivo and in vitro CRISPR/Cas9 screening systems to uncover regulators of effector B cells in the context of mouse models of type 2 immunity and allergic responses.

Student Profile
We are looking for a candidate with the following qualifications
• Practical scientific experience and a strong theoretical background in fields such as immunology, genetics, epigenetics, molecular biology or biochemistry.
• An interest in research using mice as animal models.
• A high degree of scientific curiosity, creativity, flexibility, and enthusiasm for working in an interdisciplinary and international team.

If you have any questions, feel free to contact Dr. Lesly Calderon (lesly.calderon@helmholtz-munich.de).

We look forward to receiving your application, including your letter of motivation, CV, the contact details of a referee, and academic transcripts of records.

For more information, check the Molecular Immunology laboratory website:
https://www.helmholtz-munich.de/en/iaf/research-groups/rg-calderon